CAS： 646502-53-6
All products are only used for scientific research, instead of human or animal experiments.
Cat. No.：HD00443
Formula：C68H105N11O15
Mol. Weight：1316.63
Purity：≥95%
Long Term Storage：Store in a tight container at -20℃
Description：Tubulin polymerase inhibitor
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VcMMAE (mc-vc-PAB-MMAE) is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, MMAE linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
[1] Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897.
[2] Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.
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