CAS： 1599440-33-1
All products are only used for scientific research, instead of human or animal experiments.
Cat. No.：HD00056
Formula：C26H24FN3O6
Mol. Weight：493.49
Purity：≥95%
Long Term Storage：Store in a tight container at -20°C under nitrogen.
Description：DNA topoisomerase I Inhibitor
| Size | Price, EXW | Stock | Quantity | Add to Cart |
|---|---|---|---|---|
| 25mg | $1898.00 | In stock | - 1 + | |
| 100mg | $3850.00 | In stock | - 1 + |
DXD (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
[1] Ogitani Y, et al. DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1. Clin Cancer Res. 2016 Oct 15;22(20):5097-5108.
[2] Ogitani Y, Abe Y, Iguchi T, Yamaguchi J, Terauchi T, Kitamura M, Goto K, Goto M, Oitate M, Yukinaga H, Yabe Y, Nakada T, Masuda T, Morita K, Agatsuma T. Wide application of a novel topoisomerase I inhibitor-based drug conjugation technology. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5069-5072. doi: 10.1016/j.bmcl.2016.08.082. Epub 2016 Aug 27. PubMed PMID: 27599744.
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