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Location:Home > Products > ADC Payload > N-Acetyl-Calicheamicin
N-Acetyl-Calicheamicin

CAS: 108212-76-6 (Synonyms:N-Acetyl-Calicheamicin γ; N-Acetyl-γ-calicheamicin)

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00043

Formula:C57H76IN3O22S4

Mol. Weight:1410.39

Purity:≥90%

Long Term Storage:Store in a tight container at -20℃.

Description:DNA synthesis inhibitor

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Biological Activity

N-Acetyl calicheamicin is a derivative of calicheamicin, and is a potent enediyne antitumor antibiotic. Calicheamicins target DNA and cause strand scission. Calicheamicins bind with DNA in the minor groove, wherein they then undergo a reaction analogous to the Bergman cyclization to generate a diradical species. This diradical, 1,4-didehydrobenzene, then abstracts hydrogen atoms from the deoxyribose (sugar) backbone of DNA, which ultimately leads to strand scission. The specificity of binding of calicheamicin to the minor groove of DNA was demonstrated by Crothers et al. (1999) to be due to the aryltetrasaccharide group of the molecule.

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References

[1] Stasi R, et al. Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia. Cancer Treat Rev. 2008 Feb;34(1):49-60.

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