CAS： 12684-33-2
All products are only used for scientific research, instead of human or animal experiments.
Cat. No.：HD00007
Formula：C24H33N3O7
Mol. Weight：475.53
Purity：≥95%
Long Term Storage：Store in a tight container at -20°C.
Description：A naturally produced glycosylated pyrrolobenzodiazepines
Sibiromycin, a naturally produced glycosylated pyrrolobenzodiazepines (PBDs), displays the highest affinity for DNA and the most potent antitumor properties. Sibiromycin is also a potent antitumor antibiotic that binds covalently to DNA in the minor groove at the NH2 of guanine.
[1] Wei Li, Ankush Khullar, Shenchieh Chou, Ashley Sacramo, Barbara Gerratana, Biosynthesis of sibiromycin, a potent antitumor antibiotic, Appl Environ Microbiol. 2009 May;75(9):2869-78. doi: 10.1128/AEM.02326-08. Epub 2009 Mar 6.
[2] Gerratana B. Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines. Med Res Rev. 2012;32(2):254-293.
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