CAS： 28380-24-7 （Synonyms：NIGERICIN SODIUM SALT）
All products are only used for scientific research, instead of human or animal experiments.
Cat. No.：HD00096
Formula：C40H68O11
Mol. Weight：724.96
Purity：≥95%
Long Term Storage：Store in a tight container at 2-8℃.
Description：NLRP3 activator, antibiotic
Nigericin is an antibiotic derived from Streptomyces hygroscopicus. Nigericin is also mobile in its protonated noncomplexed form, with the result that the ionophore can catalyse the overall electroneutral exchange of K+ for H+. It induces the release of IL-1β in response to the activation of the NLRP3 (also known as NALP3 or cryopyrin) inflammasome.
[1] David G. Nicholls, Stuart J. Ferguson, in Bioenergetics (Fourth Edition), 2013, Ion Transport Across Energy-Conserving Membranes, Methods in Cell Biology, 2014
[2] Steinrauf LK, Pinkerton M, Chamberlin JW (1968). "The structure of nigericin". Biochem. Biophys. Res. Commun. 33 (1): 29–31. doi:10.1016/0006-291X(68)90249-0. PMID 5696503.
[3] Mariathasan S. et al., 2006. Cryopyrin activates the inflammasome and ATP. Nature 440;228-32.
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