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Location:Home > Products > ADC Payload > Auristatin F
Auristatin F

CAS: 163768-50-1 (Synonyms:AF)

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00044

Formula:C40H67N5O8

Mol. Weight:745.99

Purity:≥95%

Long Term Storage:Store in a tight container at 2-8℃.

Description:Microtubule inhibitor

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Size Price, EXW Stock Quantity Add to Cart
10mg $70.00 In stock - 1 +
25mg $130.00 In stock - 1 +
50mg $190.00 In stock - 1 +
100mg $320.00 In stock - 1 +
1g $830.00 In stock - 1 +
Biological Activity
Auristatin F is a synthetic analog of dolastatin 10. Auristatin F is a highly potent antimitotic agent. Auristatin F inhibits tubulin polymerization. Auristatin F-antibody cunjugates have proven to be successful anticancer agents.
Product Data
References

[1] Roy S, et al. SMI-Ribosome inactivating protein conjugates selectively inhibit tumor cell growth.   Chem Commun (Camb). 2017 Apr 11;53(30):4234-4237.

[2] Powell Gray B, Kelly L, Ahrens DP, Barry AP, Kratschmer C, Levy M, Sullenger BA. Tunable cytotoxic aptamer-drug conjugates for the treatment of prostate cancer. Proc Natl Acad Sci U S A. 2018 May 1;115(18):4761-4766. doi: 10.1073/pnas.1717705115. Epub 2018 Apr 16. PubMed PMID: 29666232; PubMed Central PMCID: PMC5939073.

[3] Johansson MP, Maaheimo H, Ekholm FS. New insight on the structural features of the cytotoxic auristatins MMAE and MMAF revealed by combined NMR spectroscopy and quantum chemical modelling. Sci Rep. 2017 Nov 21;7(1):15920. doi: 10.1038/s41598-017-15674-1. PubMed PMID: 29162861; PubMed Central PMCID: PMC5698355.

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