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Location:Home > Products > ADC Payload > MMAF
MMAF

CAS: 745017-94-1 (Synonyms:Monomethylauristatin F)

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00039

Formula:C39H65N5O8

Mol. Weight:731.96

Purity:≥95%

Long Term Storage:Store in a tight container between 2-8℃.

Description:Tubulin polymerase inhibitor

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Size Price, EXW Stock Quantity Add to Cart
10mg $70.00 In stock - 1 +
25mg $130.00 In stock - 1 +
50mg $190.00 In stock - 1 +
100mg $320.00 In stock - 1 +
1g $830.00 In stock - 1 +
Biological Activity

MMAF (Monomethylauristatin F) is an antineoplastic agent and a tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A.

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References

[1] Yao X, Jiang J, Wang X, Huang C, Li D, Xie K, Xu Q, Li H, Li Z, Lou L, Fang J. A novel humanized anti-HER2 antibody conjugated with MMAE exerts potent anti-tumor activity. Breast Cancer Res Treat. 2015 Aug;153(1):123-33. doi: 10.1007/s10549-015-3503-3. Epub 2015 Aug 8. PubMed PMID: 26253944..

[2] Leal M, Wentland J, Han X, Zhang Y, Rago B, Duriga N, Spriggs F, Kadar E, Song W, McNally J, Shakey Q, Lorello L, Lucas J, Sapra P. Preclinical Development of an anti-5T4 Antibody-Drug Conjugate: Pharmacokinetics in Mice, Rats, and NHP and Tumor/Tissue Distribution in Mice. Bioconjug Chem. 2015 Nov 18;26(11):2223-32. doi: 10.1021/acs.bioconjchem.5b00205. Epub 2015 Jul 16. PubMed PMID: 26180901.

[3] Kim EG, et al. Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted CancerTherapeutics.

[4] Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.

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