CAS： 2124-57-4 （Synonyms：Menaquinone-7）
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Description：Increase the expression of osteocalcin, osteoprotegerin and RANKL mRNA
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Vitamin K2（MK-7), belongs to a class of Vitamin-K2 homologs, is originally discovered as the anti-hemorrhagic factors. It is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins.Supplementation with Vitamin K2 (Menaquinone-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS).
 Peeters FECM, et al. Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using 18F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design. Nutrients. 2018 Mar 21;10(4). pii: E386.
 Conly, J M., et al., 1994. The contribution of vitamin K2 (menaquinones) produced by the intestinal microflora to human nutritional requirements for vitamin K. The American journal of gastroenterology. 89(6): 915-23.
 Thijssen, H H., et al., 1994. Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4. The British journal of nutrition. 72(3): 415-25.
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