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Location:Home > Products > ADC Payload > DM4
DM4

CAS: 796073-69-3

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00038

Formula:C38H54ClN3O10S

Mol. Weight:780.37

Purity:≥98%

Long Term Storage:Store in a tight container at -20℃.

Description:Tubulin depolymerization

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Size Price, EXW Stock Quantity Add to Cart
10mg $210.00 In stock - 1 +
25mg $365.00 In stock - 1 +
50mg $625.00 In stock - 1 +
100mg $995.00 In stock - 1 +
1g Inquiry In stock - 1 +
Biological Activity

DM4 is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate. It is a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death.

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References
[1] Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.

[2] Coiffier B, Thieblemont C, de Guibert S, Dupuis J, Ribrag V, Bouabdallah R, Morschhauser F, Navarro R, Le Gouill S, Haioun C, Houot R, Casasnovas O, Holte H, Lamy T, Broussais F, Payrard S, Hatteville L, Tilly H. A phase II, single-arm, multicentre study of coltuximab ravtansine (SAR3419) and rituximab in patients with relapsed or refractory diffuse large B-cell lymphoma. Br J Haematol. 2016 Jun;173(5):722-30. doi: 10.1111/bjh.13992. Epub 2016 Mar 24. PubMed PMID: 27010483.

[3] Hassan R, Thomas A, Alewine C, Le DT, Jaffee EM, Pastan I. Mesothelin Immunotherapy for Cancer: Ready for Prime Time? J Clin Oncol. 2016 Dec;34(34):4171-4179. Epub 2016 Oct 31. PubMed PMID: 27863199.

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