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Location:Home > Products > ADC Payload > DM1
DM1

CAS: 139504-50-0 (Synonyms:Mertansine)

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00037

Formula:C35H48ClN3O10S

Mol. Weight:738.29

Purity:≥98%

Long Term Storage:Store in a tight container at -20℃.

Description:Tubulin depolymerization

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10mg $128.00 In stock - 1 +
25mg $198.00 In stock - 1 +
50mg $298.00 In stock - 1 +
100mg $398.00 In stock - 1 +
1g Inquiry In stock - 1 +
Biological Activity

Mertansine is a tubulin inhibitor, meaning that it inhibits the assembly of microtubules by binding to tubulin (at the rhizoxin binding site). Mertansine (DM1) is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).

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References

[1] Koniev O, Kolodych S, Baatarkhuu Z, Stojko J, Eberova J, Bonnefoy JY, Cianférani S, Van Dorsselaer A, Wagner A. MAPN: First-in-Class Reagent for Kinetically Resolved Thiol-to-Thiol Conjugation. Bioconjug Chem. 2015 Sep 3. [Epub ahead of print] PubMed PMID: 26335849.

[2] Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules.

[3] Van den Mooter T, Teuwen LA, Rutten A, Dirix L. Trastuzumab emtansine in advanced human epidermal growth factor receptor 2-positive breast cancer. Expert Opin Biol Ther. 2015 May;15(5):749-60. doi: 10.1517/14712598.2015.1036026. PubMed PMID: 25865453.

[4] Lopus M. Antibody-DM1 conjugates as cancer therapeutics. Cancer Lett. 2011 Aug 28;307(2):113-8.

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