CAS： 139504-50-0 （Synonyms：Mertansine）
All products are only used for scientific research, instead of human or animal experiments.
Cat. No.：HD00037
Formula：C35H48ClN3O10S
Mol. Weight：738.29
Purity：≥98%
Long Term Storage：Store in a tight container at -20℃.
Description：Tubulin depolymerization
| Size | Price, EXW | Stock | Quantity | Add to Cart |
|---|---|---|---|---|
| 10mg | $128.00 | In stock | - 1 + | |
| 25mg | $198.00 | In stock | - 1 + | |
| 50mg | $298.00 | In stock | - 1 + | |
| 100mg | $398.00 | In stock | - 1 + | |
| 1g | Inquiry | In stock | - 1 + |
Mertansine is a tubulin inhibitor, meaning that it inhibits the assembly of microtubules by binding to tubulin (at the rhizoxin binding site). Mertansine (DM1) is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).
[1] Koniev O, Kolodych S, Baatarkhuu Z, Stojko J, Eberova J, Bonnefoy JY, Cianférani S, Van Dorsselaer A, Wagner A. MAPN: First-in-Class Reagent for Kinetically Resolved Thiol-to-Thiol Conjugation. Bioconjug Chem. 2015 Sep 3. [Epub ahead of print] PubMed PMID: 26335849.
[2] Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules.
[3] Van den Mooter T, Teuwen LA, Rutten A, Dirix L. Trastuzumab emtansine in advanced human epidermal growth factor receptor 2-positive breast cancer. Expert Opin Biol Ther. 2015 May;15(5):749-60. doi: 10.1517/14712598.2015.1036026. PubMed PMID: 25865453.
[4] Lopus M. Antibody-DM1 conjugates as cancer therapeutics. Cancer Lett. 2011 Aug 28;307(2):113-8.
You are the 1187682 th Visitor
Phone：0086-571-86907218
Email：hdcsales@huidacollection.cn
Copyright © 2021 HuiDaCollection 浙ICP备20008217号 Designed by Wanhu