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Location:Home > Products > ADC Payload > Ansamitocin P-0
Ansamitocin P-0

CAS: 57103-68-1 (Synonyms:Maytansinol)

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00034

Formula:C28H37ClN2O8

Mol. Weight:565.05

Purity:≥98%

Long Term Storage:Store in a tight container at 2-8℃.

Description:Microtubule inhibitor

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10mg $145.00 In stock - 1 +
25mg $210.00 In stock - 1 +
50mg $295.00 In stock - 1 +
100mg $395.00 In stock - 1 +
1g Inquiry In stock - 1 +
Biological Activity

It was shown to inhibit microtubule assembly and induces microtubule disassembly in vitro. It exhibits antitumor activity. Maytansinol inhibits microtubule assembly. Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila.

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References

[1] Feng L, Yao HP, Zhou YQ, Zhou J, Zhang R, Wang MH. Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer. J Exp Clin Cancer Res. 2016 Apr 22;35:70. doi: 10.1186/s13046-016-0347-6. Erratum in: J Exp Clin Cancer Res. 2016;35(1):95. PubMed PMID: 27102688; PubMed Central PMCID: PMC4840490.

[2] Edwards A,et al. Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. Dis Model Mech. 2011 Jul;4(4):496-503. PMID:21504911.

[3] Edwards A, Gladstone M, Yoon P, Raben D, Frederick B, Su TT. Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. Dis Model Mech. 2011 Jul;4(4):496-503. doi: 10.1242/dmm.006486. Epub 2011 Apr 18. PubMed PMID: 21504911; PubMed Central PMCID: PMC3124055.

[4] Sawada T, Kato Y, Kobayashi H, Hashimoto Y, Watanabe T, Sugiyama Y, Iwasaki S. A fluorescent probe and a photoaffinity labeling reagent to study the binding site of maytansine and rhizoxin on tubulin. Bioconjug Chem. 1993 Jul-Aug;4(4):284-9. PubMed PMID: 8218485.

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