CAS： 108212-75-5
All products are only used for scientific research, instead of human or animal experiments.
Cat. No.：HD00015
Formula：C55H74IN3O21S4
Mol. Weight：1368.35
Purity：≥95%
Long Term Storage：Long term storage in a tight container at -20℃.
Description：DNA cleavage
| Size | Price, EXW | Stock | Quantity | Add to Cart |
|---|---|---|---|---|
| 10mg | $1200.00 | In stock | - 1 + | |
| 25mg | $1800.00 | In stock | - 1 + | |
| 50mg | $2550.00 | In stock | - 1 + | |
| 100mg | $3550.00 | In stock | - 1 + |
Calicheamicin, has strong anti-Gram-positive bacteria activity and anti-tumor effect, is a cytotoxic agent that causes double-strand DNA breaks. Calicheamicin is a DNA synthesis inhibitor.
[1] Damelin M, et al. Anti-EFNA4 Calicheamicin Conjugates Effectively Target Triple-Negative Breast and Ovarian Tumor-Initiating Cells to Result in Sustained Tumor Regressions. Clin Cancer Res. 2015 Sep 15;21(18):4165-73
[2] de Vries JF, et al. The novel calicheamicin-conjugated CD22 antibody inotuzumab ozogamicin (CMC-544) effectively kills primary pediatric acute lymphoblastic leukemia cells. Leukemia. 2012 Feb;26(2):255-64
[3] Takeshita A, et al. CMC-544 (inotuzumab ozogamicin), an anti-CD22 immuno-conjugate of calicheamicin, alters the levels of target molecules of malignant B-cells. Leukemia. 2009 Jul;23(7):1329-36.
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