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Location:Home > Products > ADC Payload > Thailanstatin A
Thailanstatin A

CAS: 1426953-21-0

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00002

Formula:C28H41NO9

Mol. Weight:535.63

Purity:≥95%

Long Term Storage:Store in a tight container at -20℃.

Description:DNA synthesis inhibitor

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Size Price, EXW Stock Quantity Add to Cart
10mg $220.00 In stock - 1 +
25mg $450.00 In stock - 1 +
50mg $720.00 In stock - 1 +
100mg $1150.00 In stock - 1 +
Biological Activity

Thailanstatin A reveals low nanomolar to subnanomolar cytotoxicity against a variety of human cancer cell lines. The mechanism of action (MOA) of thailanstatin A is the inhibition of spliceosome assembly.

Product Data
References

[1] Liu X, Biswas S, et al. Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43. J Nat Prod. 2013 Apr26;76(4):685-93.

[2] Puthenveetil S, Loganzo F, et al. Natural Product Splicing Inhibitors: A New Class of Antibody-Drug Conjugate (ADC) Payloads. Bioconjug Chem. 2016 Aug 17;27(8):1880-8.

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