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Location:Home > Products > Nucleotide > 1-Methylpseudouridine
1-Methylpseudouridine

CAS: 13860-38-3 (Synonyms:N1-Methylpseudouridine)

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00042

Formula:C10H14N2O6

Mol. Weight:258.23

Purity:≥98%

Long Term Storage:Store in a tight container at 2-8℃.

Description:Modified Nucleoside

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Biological Activity
1-Methylpseudouridine is a substitute for uridine in modified mRNA. This substitution has shown to increase transfection by reducing immunogenicity. The 1-methylpseudouridine substituted mRNA increases protein expression due to low immune. 1-Methylpseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density.
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References
[1] Yuri V Svitkin, et al. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density. Nucleic Acids Res. 2017 Jun 2;45(10):6023-6036.

[2] Sahin U., Kariko K., Tureci O.. mRNA-based therapeutics–developing a new class of drugs. Nat. Rev. Drug Discov. 2014; 13:759–780.

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