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1-Methylpseudouridine

CAS： 13860-38-3 （Synonyms：N1-Methylpseudouridine）

All products are only used for scientific research, instead of human or animal experiments.

Cat. No.：HD00042

Formula：C₁₀H₁₄N₂O₆

Mol. Weight：258.23

Purity：≥98%

Long Term Storage：Store in a tight container at 2-8℃.

Description：Modified Nucleoside

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Biological Activity

1-Methylpseudouridine is a substitute for uridine in modified mRNA. This substitution has shown to increase transfection by reducing immunogenicity. The 1-methylpseudouridine substituted mRNA increases protein expression due to low immune. 1-Methylpseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density.

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References

[1] Yuri V Svitkin, et al. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density. Nucleic Acids Res. 2017 Jun 2;45(10):6023-6036.

[2] Sahin U., Kariko K., Tureci O.. mRNA-based therapeutics–developing a new class of drugs. Nat. Rev. Drug Discov. 2014; 13:759–780.

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1-Methylpseudouridine

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