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Location:Home > Products > Nucleotide > 3'-O-Methylguanosine

CAS: 10300-27-3 (Synonyms:3'-OMe-Guanosine; 3-OMG)

All products are only used for scientific research, instead of human or animal experiments.

Cat. No.:HD00036


Mol. Weight:297.27


Long Term Storage:Long term storage in a tight container at 2-8℃.

Description:Modified Nucleoside

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100mg $56.00 In stock - 1 +
1g $138.00 In stock - 1 +
Biological Activity

3'-O-Methylguanosine is an endogenous methylated nucleoside found in human fluids. Methylated purine bases are present in higher amounts in tumor-bearing patients compared to healthy controls. DNA hypermethylation is a common finding in malignant cells and has been explored as a therapeutic target for hypomethylating agents. 

Product Data

[1] Morris GS, Simmonds HA, Davies PM: Use of biological fluids for the rapid diagnosis of potentially lethal inherited disorders of human purine and pyrimidine metabolism. Biomed Chromatogr. 1986 Jun;1(3):109-18.

[2] Yang TH, Hu ML: Intracellular levels of S-adenosylhomocysteine but not homocysteine are highly correlated to the expression of nm23-H1 and the level of 5-methyldeoxycytidine in human hepatoma cells with different invasion activities. Nutr Cancer. 2006;55(2):224-31.

[3] Liu Z, Liu S, Xie Z, Blum W, Perrotti D, Paschka P, Klisovic R, Byrd J, Chan KK, Marcucci G: Characterization of in vitro and in vivo hypomethylating effects of decitabine in acute myeloid leukemia by a rapid, specific and sensitive LC-MS/MS method. Nucleic Acids Res. 2007;35(5):e31. Epub 2007 Jan 30. 

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