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Location:Home > Products > Others > Granisetron
Granisetron

CAS: 109889-09-0 (Synonyms:BRL 43694)

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00385

Formula:C18H24N4O

Mol. Weight:312.41

Purity:≥95%

Long Term Storage:Store in a tight container at -20℃.

Description:A serotonin 5-HT3 receptor antagonist

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Biological Activity

Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

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References

[1] Sanger GJ, Nelson DR. Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron). Eur J Pharmacol. 1989 Jan 10;159(2):113-24.

[2] Maleki-Dizaji N, Eteraf-Oskouei T, Fakhrjou A, The effects of 5HT3 receptor antagonist granisetron on inflammatory parameters and angiogenesis in the air-pouch model of inflammation. Int Immunopharmacol. 2010 Sep;10(9):1010-6.

[3] Boccia RV, Gordan LN, Clark G, Efficacy and tolerability of transdermal granisetron for the control of chemotherapy-induced nausea and vomiting associated with moderately and highly emetogenic multi-day chemotherapy: a randomized, double-blind, phase III study. Support Care Cancer. 2011 Oct;19(10):1609-17.

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