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Location:Home > Products > Others > Wortmannin
Wortmannin

CAS: 19545-26-7

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00386

Formula:

C23H24O8

Mol. Weight:428.43

Purity:≥95%

Long Term Storage:Store in a tight container at -20℃.

Description:A potent, selective and irreversible PI3K inhibitor

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Biological Activity
Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50s of 5.8 and 48 nM, respectively
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References

[1] Yano H, et al. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem. 1993 Dec 5;268(34):25846-56.

[2] Moon EK, et al. Autophagy inhibitors as a potential antiamoebic treatment for Acanthamoeba keratitis. Antimicrob Agents Chemother. 2015 Jul;59(7):4020-5.

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