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Location:Home > Products > Immunosuppressant > Rimiducid
Rimiducid

CAS: 195514-63-7

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00316

Formula:C78H98N4O2

Mol. Weight:1411.63

Purity:≥95%

Long Term Storage:Store in a tight container at -20℃.

Description:A dimerizer agent that acts by cross-linking the FKBP domains

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Biological Activity
Rimiducid (AP1903) is a dimerizer agent that acts by cross-linking the FKBP domains. Rimiducid (AP1903) dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis.
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References

[1] Clackson T, et al. Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10437-42.

[2] Thomis DC, et al. A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease. Blood. 2001 Mar 1;97(5):1249-57.

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