CAS： 149633-99-8
All products are only used for scientific research, instead of human or animal experiments.
Cat. No.：HD00114
Formula：C30H31NO9
Mol. Weight：549.57
Purity：≥95%
Long Term Storage：Store in a tight container at -20℃.
Description：Aurora-B kinase inhibitor
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A jadomycin is an angucyclic natural product produced by Streptomyces venezuelae ISP5230 (ATCC10712), the producing organism of the antibiotic chloramphenicol.
[1] Hall SR, Toulany J, Bennett LG, Martinez-Farina CF, Robertson AW, Jakeman DL, Goralski KB. Jadomycins Inhibit Type II Topoisomerases and Promote DNA Damage and Apoptosis in Multidrug-Resistant Triple-Negative Breast Cancer Cells. J Pharmacol Exp Ther. 2017 Nov;363(2):196-210. doi: 10.1124/jpet.117.241125. Epub 2017 Sep 13. PubMed PMID: 28904004.
[2] Li L, Pan G, Zhu X, Fan K, Gao W, Ai G, Ren J, Shi M, Olano C, Salas JA, Yang K. Engineered jadomycin analogues with altered sugar moieties revealing JadS as a substrate flexible O-glycosyltransferase. Appl Microbiol Biotechnol. 2017 Jul;101(13):5291-5300. doi: 10.1007/s00253-017-8256-y. Epub 2017 Apr 20. PubMed PMID: 28429060.
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