Nikkomycins are competitive inhibitors of chitin synthase and inhibit the growth of filamentous fungi, insects, acarids and yeasts. The gene cluster responsible for biosynthesis of nikkomycins has been cloned and the biosynthetic pathway was elucidated at the genetic, enzymatic and regulatory levels.

[1] Feng C , Ling H , Du D , et al. Novel nikkomycin analogues generated by mutasynthesis in Streptomyces ansochromogenes[J]. Microbial Cell Factories, 2014, 13.