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Location:Home > Products > Agricultural Products > Validamycin A
Validamycin A

CAS: 37248-47-8

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00367

Formula:C20H35NO13

Mol. Weight:497.49

Purity:≥95%

Long Term Storage:Store in a tight container between 2-8℃, protect from light, stored under nitrogen.

Description:Fungicidal, is an agricultural antibiotic.

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Biological Activity

Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM. Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM.

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References

[1] Napasawan Plabutong, et al. The Inhibitory Effect of Validamycin A on Aspergillus flavus. Int J Microbiol. 2020; 2020: 3972415.

[2] N Asano, et al. Effect of validamycins on glycohydrolases of Rhizoctonia solani. J Antibiot (Tokyo). 1987 Apr;40(4):526-32.

[3] Zhi-Jiang Wang, et al. The effect of validamycin A on tyrosinase: inhibition kinetics and computational simulation. Int J Biol Macromol. 2013 Apr;55:15-23.

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