CAS： 33069-62-4
All products are only used for scientific research, instead of human or animal experiments.
Cat. No.：HD00392
Formula：C47H51NO14
Mol. Weight：853.91
Purity：≥95%
Long Term Storage：Store in a tight container at 2-8℃, protect from light.
Description：A compound with antineoplastic activity extracted from the Pacific yew tree Taxus brevifolia.
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Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.
[1] Choi YH, et al. Paclitaxel-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. Oncol Rep. 2012 Dec;28(6):2163-9.
[2] Dziadyk JM, et al. Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest. Anticancer Res. 2004 Jan-Feb;24(1):27-36.
[3] Li Q, et al. Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the mouse model. FEBS J. 2016 Aug;283(15):2836-52.
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