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Location:Home > Products > Immunosuppressant > Everolimus
Everolimus

CAS: 159351-69-6 (Synonyms:RAD001; SDZ-RAD)

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00423

Formula:C53H83NO14

Mol. Weight:958.22

Purity:≥95%

Long Term Storage:Store in a tight container at -20℃.

Description:Derivatives of rapamycin

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Biological Activity

Everolimus is an inhibitor of the mammalian target of rapamycin (mTOR) and has been shown to have antineoplastic activity in addition to its use as an immunosuppressive agent for the prevention of organ transplant rejection. Besides its immunosuppressive activity for the prevention of organ transplant rejection, everolimus exhibits antineoplastic activity and is currently used to treat renal cell cancer and other tumors.

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References

[1] Laura Eibenschutz, Delia Colombo, Caterina Catricalà. Everolimus for compassionate use in multiple Basal cell carcinomas. Case Rep Dermatol Med. 2013;2013:604301. doi: 10.1155/2013/604301.

[2] G Anandappa, AE Hollingdale, and TG Eisen. Everolimus – a new approach in the treatment of renal cell carcinoma. Cancer Management and Research 2010:2 61-70

[3] Raffaele Pezzani, Beatrice Rubin, Marco Redaelli, Claudia Radu, Susi Barollo, Maria Verena Cicala, Monica Salva, Caterina Mian, Carla Mucignat-Caretta, Paolo Simioni, Maurizio Iacobone and Franco Mantero. The antiproliferative effects of ouabain and everolimus on adrenocortical tumor cells. Endocrine journal, 2013

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