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Ginsenoside CK

CAS: 39262-14-1 (Synonyms:Ginsenoside compound K; Ginsenoside K)

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00253

Formula:C36H62O8

Mol. Weight:622.87

Purity:≥95%

Long Term Storage:tore in a tight container at -20℃.

Description:Bacterial metabolite of G-Rb1

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Biological Activity

Ginsenoside C-K, a bacterial metabolite of G-Rb1, exert anti-inflammatory activities in inflammatory responses by suppressing the production of pro-inflammatory cytokines and regulating the activities of inflammatory signaling pathways, such as nuclear factor-κB (NF-κB) and activator protein (AP)-1. Ginsenoside C-K exhibits an inhibition against the activity of CYP2C9 and CYP2A6 in human liver microsomes ,respectively.

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References

[1] Kim JH, et al. Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responsesand diseases. J Ginseng Res. 2017 Oct;41(4):435-443.

[2] Liu Y, et al. Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. Toxicol Sci. 2006 Jun;91(2):356-64.

[3] Zhang J, et al. Ginsenosides Regulate PXR/NF-κB Signaling and Attenuate Dextran Sulfate Sodium-Induced Colitis. Drug Metab Dispos. 2015 Aug;43(8):1181-9.

[4] Liu KK, et al. Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis. Acta Pharmacol Sin. 2014 May;35(5):599-612.

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