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Location:Home > Products > Others > Luteolin
Luteolin

CAS: 491-70-3

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00152

Formula:C15H10O6

Mol. Weight:286.24

Purity:≥95%

Long Term Storage:Store in a tight container at -20℃.

Description:Effective Nrf2 inhibitors, anti-inflammatory, anti-cancer properties

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Biological Activity

Luteoline is a flavonoid compound and an effective Nrf2 inhibitor. It has anti-inflammatory and anti-cancer properties, including inducing apoptosis and cell cycle arrest in a variety of cancer cell lines (including human non-small lung cancer cells), as well as inhibiting metastasis and angiogenesis.

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References
[1] Xiuwen Tang, et al. Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs. Free Radic Biol Med. 2011 Jun 1;50(11):1599-609.

[2] Abu-Elsaad N, et al. Protection against nonalcoholic steatohepatitis through targeting IL-18 and IL-1alpha by luteolin. Pharmacol Rep. 2019 Aug;71(4):688-694.

[3] Ma L, et al. Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of Sirt1-mediated apoptosis. Mol Med Rep. 2015 Sep;12(3):4196-4202.

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