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Location:Home > Products > Diabetes > Gliclazide
Gliclazide

CAS: 21187-98-4 (Synonyms:S1702; SE1702)

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00418

Formula:C15H21N3O3S

Mol. Weight:323.41

Purity:≥95%

Long Term Storage:Store in a tight container at -20℃.

Description:Sulfonylurea oral hypoglycemic agents

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Biological Activity

Gliclazide is a high-potency sulphonylurea which shows specificity for the pancreatic beta-cell KATP channel over heart and smooth muscle. Gliclazide counters the hydrogen peroxide-induced insulin resistance in 3T3L1 adipocytes and also would further augment the hypoglycemic effect of this drug as insulinotropic sulfonylurea.

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References

[1] C L Lawrence, P Proks, G C Rodrigo, P Jones, Y Hayabuchi, N B Standen, F M Ashcroft. Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells. Diabetologia. 2001 Aug;44(8):1019-25. doi: 10.1007/s001250100595.

[2] Tatsuhiro Shimoyama, et al., Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation. Metabolism. 2006 Jun;55(6):722-30. doi: 10.1016/j.metabol.2006.01.019.

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