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Location:Home > Products > Antitumor > Phleomycin
Phleomycin

CAS: 11006-33-0

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00068

Formula:C51H75N17O21S2

Mol. Weight:1326.4

Purity:≥95%

Long Term Storage:Store in a tight container at -20℃.

Description:Glycopeptide antibiotic

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Biological Activity
Phleomycin is an anticancer glycopeptide antibiotic found in Streptomyces verticillus, which cause DNA cleavage. Phleomycin binds and intercalates DNA to damage the integrity of the double helix.
Product Data
References
[1] Moore CW. Control of in vivo (cellular) phleomycin sensitivity by nuclear genotype, growth phase, and metal ions. Cancer Res. 1982 Mar;42(3):929-33.

[2] van Peer AF, de Bekker C, Vinck A, Wösten HA, Lugones LG. Phleomycin increases transformation efficiency and promotes single integrations in Schizophyllum commune. Appl Environ Microbiol. 2009 Mar;75(5):1243-7.

[3] Stokowa-Sołtys K, Dzyhovskyi V, Wieczorek R, Jeżowska-Bojczuk M. Phleomycin complex - Coordination mode and in vitro cleavage of DNA. J Inorg Biochem. 2019 Jun;195:71-82. 

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