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Location:Home > Products > Diabetes > Pioglitazone hydrochloride
Pioglitazone hydrochloride

CAS: 112529-15-4 (Synonyms:U 72107A; AD 4833)

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00416

Formula:C19H21ClN2O3S

Mol. Weight:392.9

Purity:≥95%

Long Term Storage:Store in a tight container at -20℃.

Description:Thiazolidinedione antidiabetic drugs

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Biological Activity
Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ.
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References

[1] Kuwabara K, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose leve

[2] Puddu A, et al. Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15. Regul Pept. 2012 Aug 20;177(1-3):79-84.

[3] Kubota N, et al. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem. 2006 Mar 31;281(13):8748-55.

[4] Elrashidy RA, et al. Pioglitazone attenuates cardiac fibrosis and hypertrophy in a rat model of diabetic nephropathy. J Cardiovasc Pharmacol Ther. 2012 Sep;17(3):324-33.

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