Schisandrin B, a dibenzocyclooctadiene derivative isolated from Schisandra chinensis and uses in traditional Chinese medicine for the treatment of hepatitis and myocardial disorders. The anti-inflammatory effects of Schisandrin B are mediated via modulation of Nrf2 and NF-κB in lymphocytes.

[1] Checker R, et al. Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-κB. Free Radic Biol Med. 2012 Oct 1;53(7):1421-30.

[2] Lam PY, et al. Schisandrin B as a hormetic agent for preventing age-related neurodegenerative diseases. Oxid Med Cell Longev. 2012;2012:250825.

[3] Zeng KW, et al. Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia. Eur J Pharmacol. 2012 Oct 5;692(1-3):29-37.