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Location:Home > Products > Diabetes > Acarbose
Acarbose

CAS: 56180-94-0

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00364

Formula:C25H43NO18

Mol. Weight:645.6

Purity:≥95%

Long Term Storage:Store in a tight container at -20℃.

Description:An orally active alpha-glucosidase inhibitor

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Biological Activity

Acarbose is an α-glucosidase inhibitor that improves glycemic control by decreasing the intestinal absorption of glucose, thereby decreasing the elevation of postprandial blood glucose. Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin.

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References

[1] Chan KC, et al. Pleiotropic effects of acarbose on atherosclerosis development in rabbits are mediated via upregulating AMPK signals. Sci Rep. 2016 Dec 7;6:3864.

[2] Yee HS, et al. A review of the safety and efficacy of acarbose in diabetes mellitus. Pharmacotherapy. 1996;16(5):792-805.

[3] Hanefeld M, et al. Acarbose: oral anti-diabetes drug with additional cardiovascular benefits [published correction appears in Expert Rev Cardiovasc Ther. 2009 Mar;7(3):330]. Expert Rev Cardiovasc Ther. 2008;6(2):153-163.

[4] Oki T, et al. Evaluation of alpha-glucosidase inhibition by using an immobilized assay system. Biol Pharm Bull. 2000;23(9):1084-1087.

[5] Zhang Q, et al. Acarbose Reduces Blood Glucose by Activating miR-10a-5p and miR-664 in Diabetic Rats. PLoS One. 2013 Nov 18;8(11):e79697.

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