CAS： 5508-58-7
All products are only used for scientific research, instead of human or animal experiments.
Cat. No.：HD00191
Formula：C20H30O5
Mol. Weight：350.45
Purity：≥95%
Long Term Storage：Store in a tight container at -20℃.
Description：NF-κB inhibitor
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Andrographolid impaired RANKL-induced NF-κB signalling by inhibiting the phosphorylation of TGF-β-activated kinase 1, suppressing the phosphorylation and degradation of IκBα. Andrographolid also inhibits the ERK/MAPK signalling pathway without affecting p38 or JNK signalling. Andrographolide possesses antiviral effects.
[1] Swati Gupta, K P Mishra, Lilly Ganju, Broad-spectrum antiviral properties of andrographolide. Arch Virol. 2017 Mar;162(3):611-623. doi: 10.1007/s00705-016-3166-3. Epub 2016 Nov 28.
[2] Z J Zhai, H W Li, G W Liu, X H Qu, B Tian, W Yan, Z Lin, T T Tang, A Qin, K R Dai, Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo. Br J Pharmacol. 2014 Feb;171(3):663-75. doi: 10.1111/bph.12463.
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