CAS： 475-81-0 （Synonyms：O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396）
All products are only used for scientific research, instead of human or animal experiments.
Cat. No.：HD00178
Formula：C21H25NO4
Mol. Weight：355.43
Purity：≥95%
Long Term Storage：Store in a tight container between 2-8℃, protect from light.
Description：Phosphodiesterase 4 (PDE4) inhibitor, non-selective α-adrenoceptor antagonist
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Glaucine is an alkaloid isolated from Glaucium flavum Crantz, a phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 µM in human bronchus and polymorphonuclear leukocytes, a non-selective α-adrenoceptor antagonist.
[1] Golo M J Meyer, et al. Studies on the in Vivo Contribution of Human Cytochrome P450s to the Hepatic Metabolism of Glaucine, a New Drug of Abuse. Biochem Pharmacol. 2013 Nov 15;86(10):1497-506.
[2] Maya Spasova, et al. Cinnamoyl- And Hydroxycinnamoyl Amides of Glaucine and Their Antioxidative and Antiviral Activities. Bioorg Med Chem. 2008 Aug 1;16(15):7457-61.
[3] J Cortijo, et al. Bronchodilator and Anti-Inflammatory Activities of Glaucine: In Vitro Studies in Human Airway Smooth Muscle and Polymorphonuclear Leukocytes. Br J Pharmacol. 1999 Aug;127(7):1641-51.
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