CAS： 64183-27-3
All products are only used for scientific research, instead of human or animal experiments.
Cat. No.：HD00083
Formula：C10H12FN5O3
Mol. Weight：269.23
Purity：≥95%
Long Term Storage：Store in a tight container between 2-8℃.
Description：Building blocks of nucleic acid
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2'-Fluoro-2'-Deoxyadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2'-Fluoro-2'-Deoxyadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde) and shows excellent in vivo activity against tumors expressing E. coli PNP.
[1] A E Hassan, et al. A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy. Nucleosides Nucleotides Nucleic Acids. 2000 Mar;19(3):559-65.
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