CAS： 159857-80-4
All products are only used for scientific research, instead of human or animal experiments.
Cat. No.：HD00087
Formula：C28H40N6O7
Mol. Weight：572.65
Purity：≥95%
Long Term Storage：Store in a tight container at 2-8 ℃.
Description：Cleavable ADC linker
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Mc-Val-Cit-PAB is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-aminobenzyl (PAB) spacer that allows the peptide to be linked to active compounds, such as anticancer agents. Mc-Val-Cit-PAB is cleaved in vivo by cathepsin B, a protease highly expressed in cancer cells, which confers specificity of the ADC to cancer cells.
[1] Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders.
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