Epothilone B丨152044-54-7丨Antitumor-HuiDaCollection丨Dedicated to the establishment of a compound library of comprehensive intermediates and active ingredients

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Epothilone B

CAS： 152044-54-7 （Synonyms：EPO 906; Patupilone）

All products are only used for scientific research, instead of human or animal experiments.

Cat. No.：HD00027

Formula：C₂₇H₄₁NO₆S

Mol. Weight：507.68

Purity：≥95%

Long Term Storage：Store in a tight container at -20°C.

Description：Microtubule stabilizer

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Biological Activity

Epothilone B, also known as Patupilone and EPO-906, is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, epothilone B induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Epothilone B may cause complete cell-cycle arrest.

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References

[1] Cheng K, Bradley T, Budman D R, et al. Novel microtubule-targeting agents - the epothilones[J]. Biologics: Targets & Therapy, 2008, 2(4): 789-811.

[2] Su D S, Meng D, Bertinato P, et al. Total Synthesis of (–)‐Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones[J]. Angewandte Chemie, 1997, 36(7): 757-759.

[3] Bollag D M, Mcqueney P A, Zhu J, et al. Epothilones, a New Class of Microtubule-stabilizing Agents with a Taxol-like Mechanism of Action[J]. Cancer Research, 1995, 55(11): 2325-2333.

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Epothilone B

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