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Location:Home > Products > Antitumor > Illudin S
Illudin S

CAS: 1149-99-1

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00064

Formula:C15H20O4

Mol. Weight:264.32

Purity:≥95%

Long Term Storage:Store in a tight container at -20℃.

Description:DNA Alkylator

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10mg $1372.00 In stock - 1 +
25mg Inquiry In stock - 1 +
Biological Activity

Illudin S is a cytotoxic Illudin, a genetically toxic natural sesquiterpene with strong anti-tumor and anti-viral activities. Illudin S blocks the G1-S phase interface of the human leukemia cell cycle.

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References

[1] Glatt H, Pietsch KE, Sturla SJ, Meinl W. Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells. Arch Toxicol. 2014 Jan;88(1):161-9.

[2] Tanaka K, Inoue T, Kadota S, Kikuchi T. Metabolism by rat liver cytosol of illudin S, a toxic substance of Lampteromyces japonicus. II. Characterization of illudin S-metabolizing enzyme. Xenobiotica. 1992 Jan;22(1):33-9.

[3] Pietsch KE, van Midwoud PM, Villalta PW, Sturla SJ. Quantification of acylfulvene- and illudin S-DNA adducts in cells with variable bioactivation capacities. Chem Res Toxicol. 2013 Jan 18;26(1):146-55.

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