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Location:Home > Products > Antitumor > Midostaurin
Midostaurin

CAS: 120685-11-2 (Synonyms:PKC412; CGP 41251)

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00121

Formula:C35H30N4O4

Mol. Weight:570.64

Purity:≥96%

Long Term Storage:Store in a tight container between 2-8℃.

Description:Protein kinase inhibitor

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Size Price, EXW Stock Quantity Add to Cart
10mg $115.00 In stock - 1 +
25mg $156.00 In stock - 1 +
50mg $212.00 In stock - 1 +
Biological Activity
Midostaurin is a multi-targeted protein kinase inhibitor, which inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases.
Product Data
References

[1] Yin OQ, Wang Y, Schran H: A mechanism-based population pharmacokinetic model for characterizing time-dependent pharmacokinetics of midostaurin and its metabolites in human subjects. Clin Pharmacokinet. 2008;47(12):807-16. doi: 10.2165/0003088-200847120-00005.

[2] New Drug Therapy Approvals 2017 (PDF). U.S. Food and Drug Administration (FDA) (Report). January 2018. Retrieved 16 September 2020.

[3] Levis M. Midostaurin approved for FLT3-mutated AML. Blood. 2017 Jun 29;129(26):3403-3406. doi: 10.1182/blood-2017-05-782292. Epub 2017 May 25. Review. PubMed PMID: 28546144.

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