Sinefungin Is a potent inhibitor of virion mRNA (guanine-7-) -methyltransferase, mRNA (nucleoside-2 ′ -) -methyltransferase and a potent inhibitor of viral proliferation [1]. Sinefungin Is a SET 7 / 9 inhibitor that improves the [2] of renal fibrosis by inhibiting H3K4 methylation.