Source from bulbus of Lycoris radiata (L. Herit.) Herb. Anti-cancer effects of Lycorine were dependent on STAT expression. We suggest that Lycorine is a potential therapeutic in prostate cancer. Inhibition of HDAC activity is responsible for at least part of the induction of cell-cycle arrest in the G0/G1 phase by Lycorine and provide a mechanistic framework for further exploring the use of Lycorine as a novel antitumor agent.