CAS： 53123-88-9 （Synonyms：Sirolimus,AY 22989）
All products are only used for scientific research, instead of human or animal experiments.
Cat. No.：HD00123
Formula：C51H79NO13
Mol. Weight：914.17
Purity：≥95%
Long Term Storage：Store in a tight container between 2-8℃, protect from light.
Description：Potent and specific mTOR inhibitor
Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor . Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC. Rapamycin is an autophagy activator, an immunosuppressant.
[1] Edwards SR, et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem, 2007, 282(18), 13395-13401.
[2] Rangaraju S, et al. Rapamycin activates autophagy and improves myelination in explant cultures from neuropathicmice. J Neurosci. 2010 Aug 25;30(34):11388-97.
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