CAS： 183506-66-3 （Synonyms：OSI 2040）
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Apicidin is a fungal metabolite shown to exhibit antiparasitic activity by the inhibition of histone deacetylase，showed a broad spectrum of antiproliferative activity against various cancer cell lines.
 J W Han 1, S H Ahn, S H Park, S Y Wang, G U Bae, D W Seo, H K Kwon, S Hong, H Y Lee, Y W Lee, H W Lee, Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin, Cancer Res. 2000 Nov 1;60(21):6068-74.
 Choi JH, Lee JY, Choi AY, Hwang KY, Choe W, Yoon KS, Ha J, Yeo EJ, Kang I. Apicidin induces endoplasmic reticulum stress- and mitochondrial dysfunction-associated apoptosis via phospholipase Cγ1- and Ca (2+)-dependent pathway in mouse Neuro-2a neuroblastoma cells. Apoptosis. 2012 Dec;17(12):1340-58.
 Ahn MY, Kang DO, Na YJ, Yoon S, Choi WS, Kang KW, Chung HY, Jung JH, Min do S, Kim HS. Histone deacetylase inhibitor, apicidin, inhibits human ovarian cancer cell migration via class II histone deacetylase 4 silencing. Cancer Lett. 2012 Dec 28;325(2):189-99.