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Atpenin A5

CAS: 119509-24-9 (Synonyms:3-[(2S,4S,5R)-5,6-dichloro-2,4-dimethylhexanoyl]-4-hydroxy-5,6-dimethoxypyridin-2(1H)-one)

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00040

Formula:C15H21Cl2NO5

Mol. Weight:366.24

Purity:≥95%

Long Term Storage:Store in a tight container at -20℃.

Description:Antifungal antibiotic isolated from Penicillium sp.

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Size Price, EXW Stock Quantity Add to Cart
10mg $215.00 In stock - 1 +
50mg $898.00 In stock - 1 +
100mg $1438.00 In stock - 1 +
Biological Activity
Originally isolated from Penicillium sp. strain. An antibiotic and antifungal agent. Highly selective, potent ubiquinone-binding site mitochondrial complex II inhibitor (IC50 values are 12 and 3.7 nM for nematode and mammalian mitochondria respectively). Stimulates mitochondrial KATP channels. Shows anti-ischemic and cardioprotective effects in vivo.
Product Data
References

[1] Satoshi Omura, et al. Atpenins, New Antifungal Antibiotics Produced By Penicillium Sp. Production, Isolation, Physico-chemical and Biological Properties. The Journal of Antibiotics, 1988, XLI(12): 1769-1773.

[2] Hiroko Miyadera, et al. Atpenins, potent and specific inhibitors of mitochondrial complex II (succinateubiquinone oxidoreductase). PNAS, 2003, 100(2): 473-477.

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