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Location:Home > Products > Biochemical Reagent > Brefeldin A
Brefeldin A

CAS: 20350-15-6

All products are only used for scientific research, instead of human or animal experiments.


Cat. No.:HD00054

Formula:C16H24O4

Mol. Weight:280.36

Purity:≥99%

Long Term Storage:Store in a tight container at -20°C.

Description:Protein trafficking inhibitor;Antitumor, Antiviral

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Size Price, EXW Stock Quantity Add to Cart
50mg $160.00 In stock - 1 +
100mg $260.00 In stock - 1 +
500mg $1050.00 In stock - 1 +
1g $1450.00 In stock - 1 +
Biological Activity

Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus.Brefeldin A (BFA) is a fungal metabolite. It exhibits a wide range of antibiotic activity.

Product Data
References

[1] Kaczmarek B, Verbavatz JM, Jackson CL. GBF1 and Arf1 function in vesicular trafficking, lipid homoeostasis and organelle dynamics. Biol Cell. 2017 Dec;109(12):391-399. doi: 10.1111/boc.201700042. Epub 2017 Nov 6. Review. PubMed PMID: 28985001.

[2] Valente C, Luini A, Corda D. Components of the CtBP1/BARS-dependent fission machinery. Histochem Cell Biol. 2013 Oct;140(4):407-21. doi: 10.1007/s00418-013-1138-1. Epub 2013 Sep 1. Review. PubMed PMID: 23996193.

[3] Foulquier F. COG defects, birth and rise! Biochim Biophys Acta. 2009 Sep;1792(9):896-902. doi: 10.1016/j.bbadis.2008.10.020. Epub 2008 Nov 6. Review. PubMed PMID: 19028570.

[4] Arduino D, Silva D, Cardoso SM, Chaves S, Oliveira CR, Santos MA. New hydroxypyridinone iron-chelators as potential anti-neurodegenerative drugs. Front Biosci. 2008 May 1;13:6763-74. Review. PubMed PMID: 18508693.

[5] Nozawa N, et al. Subcellular localization of herpes simplex virus type 1 UL51 protein and role of palmitoylation in Golgi apparatus targeting. J Virol. 2003 Mar;77(5):3204-16.

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