It is produced by the strain of Chaetomium cochloides , Ch.globosum, Ch.fuunienlum, Ch.elatun, Ch.spirale and Verticillium cinnabarium. Chetomin is a natural metabolite produced by several species of the genus chaetomium. It is an epidithiodioxopiperazine and is an inhibitor of hypoxia-inducible factor (HIF). It inhibits interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) protein (CBP). It decreases tumor growth by attenuating hypoxia-inducible transcription and disrupting the ability of tumors to adapt to hypoxia. It also suppresses the proliferation of LPS-induced mouse spleen lymphocytes. It may be used as an antibacterial agent and is used in antitumor research. It also may be useful in radiotherapeutic.